NNC-711 hydrochloride
Cat. No.：YN1730133
| 产品名称: | NNC-711 hydrochloride |
| CAS No.: | 145645-62-1 |
| Chemical Name: | 1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid, monohydrochloride |
| Synonyms: | NO-711 hydrochloride |
| 分子量: | 386.8717 |
| 分子式: | C21H22N2O3 • HCl |
| SMILES: | OC(C1=CCCN(CCO/N=C(C2=CC=CC=C2)/C3=CC=CC=C3)C1)=O.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NNC-711 (hydrochloride) 是一种有效且选择性的 GAT-1 (GABA 转运体 1) 抑制剂，对 hGAT-1 的 IC50为 40 nM。NNC-711 在体内具有抗惊厥和镇痛作用，并表现出认知增强活性。 |
| IC50和靶点: | |
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Borden, L.A., Murali Dhar, T.G., Smith, K.E., et al.Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1Eur. J. Pharmacol.269(2),219-224(1994)
Suzdak, P.D., Frederiksen, K., Andersen, K.A., et al.NNC-711, a novel potent and selective γ-aminobutyric acid uptake inhibitor: Pharmacological characterizationEur. J. Pharmacol.224(2-3),189-198(1992)
Li, Y., Li, Y., Gu, P., et al.Analgesic effect of intrathecally γ-aminobutyric acid transporter-1 inhibitor NO-711 administrating on neuropathic pain in ratsNeurosci. Lett.494(1),6-9(2011)
