AT7519 Hydrochloride
Cat. No.：YN270408
CAS No. ：902135-91-5
| 产品名称: | AT7519 Hydrochloride |
| CAS No.: | 902135-91-5 |
| Chemical Name: | 4-[(2,6-dichlorobenzoyl)amino]-N-4-piperidinyl-1H-pyrazole-3-carboxamide, monohydrochloride |
| Synonyms: | AT7519 HCl,AT 7519 hydrochloride salt |
| 分子量: | 418.71 |
| 分子式: | C₁₆H₁₈Cl₃N₅O₂ |
| SMILES: | O=C(C(C(Cl)=CC=C1)=C1Cl)NC2=CNN=C2C(NC3CCNCC3)=O.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AT7519 Hydrochloride 是一种有效的CDK抑制剂，对 CDK1，CDK2，CDK4-CDK6 以及 CDK9 的IC50值分别为 210，47，100，13，170 和 <10 nM。 |
| IC50和靶点: | [{name:"CDK9/Cyclin T:10 nM (IC50)"},{name: "CDK5/p35:13 nM (IC50)"},{name: "cdk2/cyclin A:47 nM (IC50)"},{name: "Cdk4/cyclin D1:100 nM (IC50)"},{name: "cdk6/cyclin D3:170 nM (IC50)"},{name: "Cdk1/cyclin B:210 nM (IC50)"},{name: "CDK7/Cyclin H/MAT1:2400 nM (IC50)"},{name: "GSK3β:89 nM (IC50)"}] |
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Squires, M.S., Feltell, R.E., Wallis, N.G., et al.Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell linesMol. Cancer Ther.8(2),324-332(2009)
Santo, L., Vallet, S., Hideshima, T., et al.AT7519, a novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-βactivation and RNA polymerase II inhibitionOncogene29(16),2325-2336(2010)
