CK-636
Cat. No.：YN300041
CAS No. ：442632-72-6
| 产品名称: | CK-636 |
| CAS No.: | 442632-72-6 |
| Chemical Name: | N-[2-(2-methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide |
| Synonyms: | CK-0944636 |
| 分子量: | 284.38 |
| 分子式: | C₁₆H₁₆N₂OS |
| SMILES: | O=C(C1=CC=CS1)NCCC2=C(C)NC3=C2C=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CK-636是具有细胞渗透性的Arp2/3复合体抑制剂，能抑制肌动蛋白的聚合，对人，裂殖酵母和牛的IC50值分别为4 μM，24 μM和32 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Nolen, B.J., Tomasevic, N., Russell, A., et al.Characterization of two classes of small molecule inhibitors of Arp2/3 complexNature460(7258),1031-1034(2009)
Zhou, K., Muroyama, A., Underwood, J., et al.Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formationProc. Natl. Acad. Sci. USA110(40),E3820-E3829(2013)
Kwon, K.W., Park, H., and Doh, J.Migration of T cells on surfaces containing complex nanotopographyPLoS One8(9),e73960(2013)
