CK-666
Cat. No.：YN300043
| 产品名称: | CK-666 |
| CAS No.: | 442633-00-3 |
| Chemical Name: | 2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-benzamide |
| Synonyms: | CK 666;2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide;2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-benzamide;CK-0944666 |
| 分子量: | 296.34 |
| 分子式: | C₁₈H₁₇FN₂O |
| SMILES: | O=C(NCCC1=C(C)NC2=C1C=CC=C2)C3=CC=CC=C3F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CK-666 是一种细胞渗透性的与肌动蛋白相关的蛋白质Arp2/3复合物的抑制剂，它结合 Arp2/3 复合物，稳定复合物的非活性状态，阻止 Arp2 和 Arp3 亚单位移动进入激活的丝状构象。 |
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Nolen, B.J., Tomasevic, N., Russell, A., et al.Characterization of two classes of small molecule inhibitors of Arp2/3 complexNature460(7258),1031-1034(2009)
Hetrick, B., Han, M.S., Helgeson, L.A., et al.Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational changeChem. Biol.20(5),701-712(2013)
Ilatovskaya, D.V., Chubinskiy-Nadexhdin, V., Pavlov, T.S., et al.Arp2/3 complex inhibitors adversely affect actin cytoskeleton remodeling in the cultured murine kidney collecting duct M-1 cellsCell Tissue Res.354(3),783-792(2013)
Basu, S., Kustanovich, I., and Lamprecht, R.Arp2/3 and VASP are essential for fear memory formation in lateral amygdalaeNeuro3(6),pii:ENEURO.0302-0316.2016(2016)
