Latrunculin A
Cat. No.：YN300046
CAS No. ：76343-93-6
| 产品名称: | Latrunculin A |
| CAS No.: | 76343-93-6 |
| Chemical Name: | (4R)-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-2-thiazolidinone |
| Synonyms: | LAT-A |
| 分子量: | 421.55 |
| 分子式: | C₂₂H₃₁NO₅S |
| SMILES: | O=C1SC[C@@H]([C@]2(O)O[C@]3([H])CC[C@H](C)/C=C\C=C\CC/C(C)=C\C(O[C@@](C3)([H])C2)=O)N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Latrunculin A (LAT-A) 是从红海海绵Latrunculia magnifica中得到的一种毒素，能够与肌动蛋白 (actin) 单体结合，抑制肌动蛋白聚集，对 ATP-actin，ADP-Pi-actin，ADP-actin 和 G-actin 的Kd值分别为 0.1，0.4，4.7 μM 和 0.19 μM。 |
| IC50和靶点: | |
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Coué, M., Brenner, S.L., Spector, I., et al.Inhibition of actin polymerization by latrunculin AFEBS Lett.213(2),316-318(1987)
Yarmola, E.G., Somasundaram, T., Boring, T.A., et al.Actin-latrunculin A structure and functionJ. Biol. Chem.275(36),28120-28127(2000)
Loubéry, S., Wilhelm, C., Hurbain, I., et al.Different microtubule motors move early and late endocytic compartmentsTraffic9,492-509(2008)
Hayot, C., Debeir, O., Van Ham, P., et al.Characterization of the activities of actin-affecting drugs on tumor cell migrationToxicol. Appl. Pharmacol.211,30-40(2006)
Lyubimova, A., Bershadsky, A.D., and Ben-Ze'ev, A.Autoregulation of actin synthesis requires the 3'-UTR of actin mRNA and protects cells from actin overproductionJ. Cell. Biochem.76,1-12(1999)
Liu, X., Wu, Z., Sheibani, N., et al.Low dose latrunculin-A inhibits dexamethasone-induced changes in the actin cytoskeleton and alters extracellular matrix protein expression in cultured human trabecular meshwork cellsExp. Eye Res.77,181-188(2003)
