Dihydrocytochalasin B
Cat. No.：YN300063
| 产品名称: | Dihydrocytochalasin B |
| CAS No.: | 39156-67-7 |
| Chemical Name: | (5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-4,5,6,7,8,9,10,12a,13,14,15,15a,16,17-tetradecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(3H)-dione |
| Synonyms: | |
| 分子量: | 481.62 |
| 分子式: | C₂₉H₃₉NO₅ |
| SMILES: | O=C1[C@]2(O3)[C@]([C@@H](C([C@@H](O)[C@]2([H])/C=C/C[C@@H](CCC[C@@H](O)CCC3=O)C)=C)C)([H])[C@H](CC4=CC=CC=C4)N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dihydrocytochalasin B 二氢细胞松弛素 B 是一种细胞分裂抑制剂 (Cytokinesis)，可改变细胞的形态，与细胞松弛素 B 相似。Dihydrocytochalasin B 不抑制葡萄糖转运。Dihydrocytochalasin B 二氢细胞松弛素 B 破坏肌动蛋白结构并抑制生长因子刺激 DNA 合成的能力，可逆地阻断 DNA 合成的起始。Dihydrocytochalasin B 二氢细胞松弛素 B 抑制活性钙转运。 |
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Martineau, S.N., Andreassen, P.R., and Margolis, R.L.Delay of HeLa cell cleavage into interphase using dihydrocytochalasin B: Retention of a postmitotic spindle and telophase disc correlates with synchronous cleavage recoveryJ. Cell. Biol.131(1),191-205(1995)
Andreassen, P.R., Lohez, O.D., Lacroix, F.B., et al.Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1Mol. Biol. Cell12(5),1315-1328(2001)
Trendowski, M., Christen, T.D., Acquafondata, C., et al.Effects of cytochalasin congeners, microtubule-directed agents, and doxorubicin alone or in combination against human ovarian carcinoma cell lines in vitroBMC Cancer15:632,(2015)
