Barasertib-HQPA
Cat. No.：YN290028
CAS No. ：722544-51-6
| 产品名称: | Barasertib-HQPA |
| CAS No.: | 722544-51-6 |
| Chemical Name: | 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-3-acetamide |
| Synonyms: | AZD2811; INH-34; AZD1152-HQPA |
| 分子量: | 507.56 |
| 分子式: | C₂₆H₃₀FN₇O₃ |
| SMILES: | O=C(CC1=NNC(NC2=C3C=CC(OCCCN(CCO)CC)=CC3=NC=N2)=C1)NC4=CC=CC(F)=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Barasertib-HQPA (AZD2811) 是一种高度选择性的极光激酶B抑制剂，在非细胞试验中IC50值为0.37 nM。Barasertib-HQPA (AZD2811) 对Aurora B 的选择性是Aurora A的3700倍。 |
| IC50和靶点: | [{name:"Aurora B:0.37 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Mortlock, A.A., Foote, K.M., Heron, N.M., et al.Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinaseJ. Med. Chem.50(9),2213-2224(2007)
Yang, J., Ikezoe, T., Nishioka, C., et al.AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivoBlood110(6),2034-2040(2007)
Wilkinson, R.W., Odedra, R., Heaton, S.P., et al.AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosisClin. Cancer. Res13(12),3682-3688(2007)
