NU6140
Cat. No.：YN290076
CAS No. ：444723-13-1
| 产品名称: | NU6140 |
| CAS No.: | 444723-13-1 |
| Chemical Name: | 4-[[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino]-N,N-diethyl-benzamide |
| Synonyms: | NU6140; NU-6140; NU 6140. |
| 分子量: | 422.52 |
| 分子式: | C₂₃H₃₀N₆O₂ |
| SMILES: | CCN(CC)C(C(C=C1)=CC=C1NC2=NC(OCC3CCCCC3)=C4C(N=CN4)=N2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NU6140 是一种选择性的CDK2-cyclin A抑制剂 (IC50，0.41 μM)，对其选择性是对其他 CDK 的 10-36 倍。NU6140 有效抑制Aurora A和Aurora B的活性，IC50值分别为 67 和 35 nM。增强诱导凋亡的作用，抗肿瘤作用。 |
| IC50和靶点: | [{name:"cdk2-cyclin A:0.41 μM (IC50)"},{name: "CDK1-Cyclin B:6.6 μM (IC50)"},{name: "CDK4-Cyclin D:5.5 μM (IC50)"},{name: "cdk5-p25:15 μM (IC50)"},{name: "cdk7-cyclin H:3.9 μM (IC50)"},{name: "Aurora A:67 nM (IC50)"},{name: "Aurora B:35 nM (IC50)"}] |
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Pennati, M., Campbell, A.J., Curto, M., et al.Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: A possible role for survivin down-regulationMol. Cancer Ther.4(9),1328-1337(2005)
