CCT129202
Cat. No.：YN290171
CAS No. ：942947-93-5
| 产品名称: | CCT129202 |
| CAS No.: | 942947-93-5 |
| Chemical Name: | 4-[6-chloro-2-[4-(dimethylamino)phenyl]-3H-imidazo[4,5-b]pyridin-7-yl]-N-2-thiazolyl-1-piperazineacetamide |
| Synonyms: | 2-[4-[6-氯-2-(4-二甲基氨基苯基)-3H-咪唑并[4,5-B]吡啶-7-基]哌嗪-1-基]-N-(噻唑-2-基)乙酰胺 |
| 分子量: | 497.02 |
| 分子式: | C₂₃H₂₅ClN₈OS |
| SMILES: | CN(C1=CC=C(C2=NC3=C(C(Cl)=CN=C3N2)N4CCN(CC4)CC(NC5=NC=CS5)=O)C=C1)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CCT129202 是极光激酶 (aurora) 抑制剂，对极光激酶 A，B，C 的IC50值分别为42，198 和227 nM。 |
| IC50和靶点: | [{name:"Aurora A:42 nM (IC50)"},{name: "Aurora B:198 nM (IC50)"},{name: "Aurora C:227 nM (IC50)"}] |
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| Solvent & Solubility: |
Chan, F., Sun, C., Perumal, M., et al.Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activityMol. Cancer Ther.6(12 Pt 1),3147-3157(2007)
Cheng, C., Liu, Z.-G., Zheng, H., et al.Enhancing chemosensitivity in ABCB1- and ABCG2-overexpressing cells and cancer stem-like cells by an Aurora kinase inhibitor CCT129202Mol. Pharm.9(7),1971-1982(2012)
