Cl-amidine TFA
Cat. No.：YN310389
| 产品名称: | Cl-amidine TFA |
| CAS No.: | 1043444-18-3 |
| Chemical Name: | |
| Synonyms: | Cl-Amidine (trifluoroacetate salt);Cl-amidine (TFA);(2S)-5-(2-Chloroethanimidamido)-2-(phenylformamido)pentanamide trifluoroacetic acid salt;s8141;ZB1554;Cl-amidine 2,2,2-trifluoroacetic acid;(S)-N-(1-amino-5-(2-chloroacetimidamido)-1-oxopentan-2-yl)benza |
| 分子量: | 424.8 |
| 分子式: | C14H19ClN4O2.C2HF3O2 |
| SMILES: | C1=CC=C(C=C1)C(=O)NC(CCCN=C(CCl)N)C(=O)N.C(=O)(C(F)(F)F)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cl-amidine TFA 是口服有效的PAD抑制剂，其对 PAD1、PAD3 和 PAD4 的IC50值分别为0.8 μM、 6.2 μM 和5.9 μM。Cl-amidine TFA 可诱导癌细胞的凋亡。Cl-amidine TFA 可诱导 miR-16 (miRNA-16, microRNA-16)，引起细胞周期阻滞。Cl-Amidine TFA 可阻断组蛋白 3 瓜氨酸化和中性粒细胞胞外陷阱的形成，并提高败血症小鼠的存活率。 |
| IC50和靶点: | |
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