Protein kinase inhibitor H-7 dihydrochloride
Cat. No.：YN310392
CAS No. ：108930-17-2
| 产品名称: | Protein kinase inhibitor H-7 dihydrochloride |
| CAS No.: | 108930-17-2 |
| Chemical Name: | 5-[(2-methyl-1-piperazinyl)sulfonyl]-isoquinoline, dihydrochloride |
| Synonyms: | H7 dihydrochloride; H7 HCl. |
| 分子量: | 364.3 |
| 分子式: | C14H17N3O2S • 2HCl |
| SMILES: | O=S(C1=CC=CC2=CN=CC=C21)(N3C(C)CNCC3)=O.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Protein kinase inhibitor H-7 dihydrochloride 是一种有效的PKC蛋白激酶 C 抑制剂。在 100 μM 时，Protein kinase inhibitor H-7 dihydrochloride 完全抑制TPA(皮肤肿瘤启动子，12-O-tetradecanoylphorbol-13-acetate) 和磷脂酶 C 诱导的ODC(鸟氨酸脱羧酶)。 |
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Qatsha, K.A., Rudolph, C., Marmé, D., et al.Gö 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level-producing reservoir cells in vitroProc. Natl. Acad. Sci. USA90(10),4674-4678(1993)
Kumahara, E., Ebihara, T., and Saffen, D.Protein kinase inhibitor H7 blocks the induction of immediate-early genes zif268 and c-fos by a mechanism unrelated to inhibition of protein kinase C but possibly related to inhibition of phosphorylation of RNA polymerase IIJ. Biol. Chem.274(15),10430-10438(1999)
