BS-181
Cat. No.：YN290569
| 产品名称: | BS-181 |
| CAS No.: | 1092443-52-1 |
| Chemical Name: | |
| Synonyms: | BS-181 hydrochloride;BS-181;5-N-(6-aminohexyl)-7-N-benzyl-3-propan-2-ylpyrazolo[1,5-a]pyrimidine-5,7-diamine,hydrochloride;BS181;N5-(6-aminohexyl)-N7-benzyl-3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diamine;BCP9000454;BCPP000314;BS-181 HCl;cc-578;N5-(6-ami |
| 分子量: | 380.54 |
| 分子式: | C22H32N6 |
| SMILES: | CC(C1=C(N=C(C=C2NCC3=CC=CC=C3)NCCCCCCN)N2N=C1)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BS-181 是一种有效的CDK7选择性抑制剂 (IC50=21 nM)，与 Seliciclib (HY-30237) 相比。BS-181 抑制CDK2、CDK5 和CDK9的IC50值分别为 880 nM、3000 nM 和 4200 nM (不能阻断 CDK1、4 和 6)。BS-181 抑制一组癌细胞生长 (IC50=11.5 μM-37.3 μM)，诱导细胞凋亡 (apoptosis)。BS-181 具有癌症研究相关研究的潜力。 |
| IC50和靶点: | [{name:"CDK7/CycH/MAT1:0.021 μM (IC50)"},{name: "CDK2/Cyc E:0.88 μM (IC50)"},{name: "CDK1/cycB:8.1 μM (IC50)"},{name: "CDK4/Cyc D1:33 μM (IC50)"},{name: "CDK5/p35NCK:3 μM (IC50)"},{name: "CDK6/cycD1:47 μM (IC50)"},{name: "CDK9/cycT:4.2 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
