Takeda-6D
Cat. No.：YN290576
| 产品名称: | Takeda-6D |
| CAS No.: | 1125632-93-0 |
| Chemical Name: | 2-chloro-3-(1-cyanocyclopropyl)-N-[5-[[2-[(cyclopropylcarbonyl)amino][5,4-b]pyridin-5-yl]oxy]-2-fluorophenyl]-benzamide |
| Synonyms: | Takeda 6d,Takeda6d |
| 分子量: | 547.9887632 |
| 分子式: | C27H19ClFN5O3S |
| SMILES: | N#CC1(CC1)C2=C(Cl)C(C(N([H])C3=CC(OC4=NC5=C(C=C4)N=C(N([H])C(C6CC6)=O)S5)=CC=C3F)=O)=CC=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Takeda-6D (compound 6d) 是一种口服有效的BRAF/VEGFR2抑制剂，IC50分别为 7.0 和 2.2 nM。Takeda-6D 在 293/KDR 和VEGF刺激的 HUVEC 细胞中通过抑制VEGFR2通路表现出抗血管生成的作用。Takeda-6D 显著抑制ERK1/2磷酸化。Takeda-6D 具有抗肿瘤活性。 |
| IC50和靶点: | [{name:"VEGFR2:2.2 nM (IC50)"},{name: "Braf:7.0 nM (IC50)"}] |
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Okaniwa, M., Hirose, M., Imada, T., et al.Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffoldsJ. Med. Chem.55(7),3452-3478(2012)
