IXA4
Cat. No.：YN290584
CAS No. ：1185329-96-7
| 产品名称: | IXA4 |
| CAS No.: | 1185329-96-7 |
| Chemical Name: | N-methyl-N-[2-(4-methylphenoxy)ethyl]-4-[(1-oxo-3-phenoxypropyl)amino]-1H-pyrazole-1-acetamide |
| Synonyms: | |
| 分子量: | 436.50368 |
| 分子式: | C24H28N4O4 |
| SMILES: | O=C(N(C)CCOC1=CC=C(C)C=C1)CN2N=CC(NC(CCOC3=CC=CC=C3)=O)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | IXA4 是一种高选择性、无毒的IRE1/XBP1s激活剂。IXA4 激活IRE1/XBP1s 信号，而没有全局激活未折叠蛋白反应 (UPR) 或其他应激反应信号通路 (例如热休克反应或氧化应激反应)。IXA4 通过激活IRE1减少 APP 分泌。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Madhavan, A., Kok, B.P., Rius, B., et al.Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesityNat. Commun.13(1),608(2022)
