Ep300/CREBBP-IN-8
Cat. No.：YN310400
| 产品名称: | Ep300/CREBBP-IN-8 |
| CAS No.: | 1197996-80-7 |
| Chemical Name: | 1,1'-[9-[2-[(1-methylethyl)amino]ethyl]-9H-carbazole-3,6-diyl]bis-ethanone |
| Synonyms: | Curaxin 137; CBL-C137 |
| 分子量: | 336.4 |
| 分子式: | C21H24N2O2 |
| SMILES: | CC(C1=CC=C2C(C(C=C(C(C)=O)C=C3)=C3N2CCNC(C)C)=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CBL0137 是一种 curaxin 化合物，是一种组蛋白伴侣促进染色质转录(FACT)抑制剂。CBL0137 下调NF-?B并激活p53。CBL0137 可恢复组蛋白 H3 乙酰化和三甲基化。CBL0137 是一种抗癌剂。CBL0137 诱导癌细胞凋亡 (apoptosis)。 |
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Gasparian, A.V., Burkhart, C.A., Purmal, A.A., et al.Curaxins: Anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACTSci. Transl. Med.3(95),(2011)
Burkhart, C., Fleyshman, D., Kohrn, R., et al.Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancerOncotarget5(22),11038-11053(2014)
