Tyrphostin AG213
Cat. No.:YN290589
产品名称: | Tyrphostin AG213 |
CAS No.: | 122520-86-9 |
Chemical Name: | 2-cyano-3-(3,4-dihydroxyphenyl)-2E-propenethioamide |
Synonyms: | AG213 |
分子量: | 220.2 |
分子式: | C10H8N2O2S |
SMILES: | N#C/C(=C\c1ccc(O)c(O)c1)/C(=S)N |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | Tyrphostin AG213 (AG213) 是一种表皮生长因子受体 (EGFR) 蛋白酪氨酸激酶抑制剂 (IC50=0.85 μM)。Tyrphostin AG213 抑制酪氨酸激酶活性 (IC50=2.4 μM) 和拓扑异构酶 II (IC100=50 μM)。Tyrphostin AG213 还能够诱导肿瘤细胞发生非凋亡类型的细胞编程性死亡。 |
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Gazit, A., Yaish, P., Gilon, C., et al.Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitorsJ. Med. Chem.32(10),2344-2352(1989)