(E/Z)-Rigosertib sodium
Cat. No.：YN290590
| 产品名称: | (E/Z)-Rigosertib sodium |
| CAS No.: | 1225497-78-8 |
| Chemical Name: | N-[2-methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]-glycine, monosodium salt |
| Synonyms: | ON01910; ON 01910; ON-01910; Rigosertib sodium; brand name: Estybon. |
| 分子量: | 473.5 |
| 分子式: | C21H25NO8S • Na |
| SMILES: | COC1=CC=C(CS(/C=C/C2=C(OC)C=C(OC)C=C2OC)(=O)=O)C=C1NCC([O-])=O.[Na+] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rigosertib (ON-01910) 是一种生化试剂，可作为生物材料或有机化合物，用于生命科学相关研究。 |
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Gumireddy, K., Reddy, M.V.R., Cosenza, S.C., et al.ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agentCancer Cell7(3),275-286(2005)
Chapman, C.M., Sun, X., Roschewski, M., et al.ON 01910.Na is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stressClin. Cancer Res.18(7),1979-1991(2012)
Oussenko, I.A., Holland, J.F., Reddy, E.P., et al.Effect of ON 01910.Na, an anticancer mitotic inhibitor, on cell-cycle progression correlates with RanGAP1 hyperphosphorylationCancer Res.71(14),4968-4976(2011)
Chang, K.C., Chang, W.C., Chang, Y., et al.Ran GTPase-activating protein 1 is a therapeutic target in diffuse large B-cell lymphomaPLoS One8(11),1-12(2013)
