7-Oxostaurosporine
Cat. No.：YN310410
| 产品名称: | 7-Oxostaurosporine |
| CAS No.: | 125035-83-8 |
| Chemical Name: | (9S,10R,11R,13R)-10,11,12,13-tetrahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonine-1,3(2H)-dione |
| Synonyms: | |
| 分子量: | 480.5 |
| 分子式: | C28H24N4O4 |
| SMILES: | [H][C@]12N(C3=C(N([C@](O2)(C)[C@H](OC)[C@H](NC)C1)C4=C5C=CC=C4)C5=C(C(NC6=O)=O)C6=C37)C8=C7C=CC=C8 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 7-Oxostaurosporine 是一种有效的蛋白激酶 C (PKC) 抑制剂，可通过诱导细胞凋亡(apoptosis) 和抑制核因子 (NF)-κB/p-p65 通路有效抑制肿瘤生长。 |
| IC50和靶点: | |
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Osada, H., Koshino, H., Kudo, T., et al.A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I. Taxonomy and biological activityJ. Antibiot. (Tokyo)45(2),189-194(1992)
Caravatti, G., Meyer, T., Fredenhagen, A., et al.Inhibitory activity and selectivity of staurosporine derivatives towards protein kinase CBioorg. Med. Chem. Lett.4(3),399-404(1994)
Wakusawa, S., Inoko, K., Miyamoto, K.-I., et al.Staurosporine derivatives reverse multidrug resistance without correlation with their protein kinase inhibitory activitiesJ. Antibiot. (Tokyo)46(2),353-355(1993)
Maekawa, M., Lee, M., Wei, K., et al.Staurosporines decrease ORMDL proteins and enhance sphingomyelin synthesis resulting in depletion of plasmalemmal phosphatidylserineSci. Rep.6:35762,(2016)
Hwang, E.-I., Yun, B.-S., Lee, S.-H., et al.7-oxostaurosporine selectively inhibits the mycelial form of Candida albicansJ. Microbiol. Biotechnol.14(5),1067-1070(2004)
