JGB1741
Cat. No.：YN290593
CAS No. ：1256375-38-8
| 产品名称: | JGB1741 |
| CAS No.: | 1256375-38-8 |
| Chemical Name: | 4,5,6,7-tetrahydro-2-[(E)-[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(phenylmethyl)-benzo[b]thiophene-3-carboxamide |
| Synonyms: | ILS-JGB-1741 |
| 分子量: | 440.6 |
| 分子式: | C27H24N2O2S |
| SMILES: | OC1=C(/C=N/C2=C(C(NCC3=CC=CC=C3)=O)C(CCCC4)=C4S2)C(C=CC=C5)=C5C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JGB1741 (ILS-JGB-1741) 是一种有效且特异性的SIRT1活性抑制剂，IC50为 ~15 μM。JGB1741 对SIRT2和SIRT3具有弱的抑制作用，IC50>100 μM。JGB1741 通过调节 Bax/Bcl2 比率、细胞色素 c 释放和PARP裂解来增加乙酰化 p53 水平，导致 p53 介导的细胞凋亡。JGB1741 具有用于乳腺癌研究的潜力。 |
| IC50和靶点: | [{name:"SIRT1:∼15 μM (IC50)"},{name: "SIRT2:>100 μM (IC50)"},{name: "SIRT3:>100 μM (IC50)"}] |
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Yamamoto, H., Schoonjans, K., and Auwerx, J.Sirtuin functions in health and diseaseMol. Endocrinol.21(8),1745-1755(2007)
Milne, J.C., and Denu, J.M.The sirtuin family: Therapeutic targets to treat diseases of agingCurr. Opin. Chem. Biol.12(1),11-17(2008)
Kalle, A.M., Mallika, A., Badiger, J., et al.Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cellsBiochem. Biophys. Res. Commun.401(1),13-19(2010)
