PTC299
Cat. No.：YN290594
CAS No. ：1256565-36-2
| 产品名称: | PTC299 |
| CAS No.: | 1256565-36-2 |
| Chemical Name: | (1S)-6-chloro-1,3,4,9-tetrahydro-1-(4-methoxyphenyl)-2H-pyrido[3,4-b]indole-2-carboxylic acid, 4-chlorophenyl ester |
| Synonyms: | PTC-299;PTC 299 |
| 分子量: | 467.34338 |
| 分子式: | C25H20Cl2N2O3 |
| SMILES: | ClC(C=C1)=CC=C1OC(N2[C@](C3=CC=C(C=C3)OC)([H])C4=C(CC2)C5=CC(Cl)=CC=C5N4)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PTC299 是VEGFA mRNA翻译的具有口服活性抑制剂，在转录后水平选择性地抑制VEGF蛋白的合成。PTC299 也是二氢乳酸盐脱氢酶(DHODH)的有效抑制剂。PTC299 良好的口服生物利用度，缺乏脱靶激酶抑制和骨髓抑制。PTC299 可用于血液系统恶性肿瘤的研究。 |
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Cao, L., Weetall, M., Trotta, C., et al.Targeting of hematologic malignancies with PTC299, a novel potent inhibitor of dihydroorotate dehydrogenase with favorable pharmaceutical propertiesMol. Cancer Ther.18(1),3-16(2019)
Luban, J., Sattler, R.A., Mühlberger, E., et al.The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokinesVirus Res.292,198246(2021)
