2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
Cat. No.：YN310411
| 产品名称: | 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide |
| CAS No.: | 1258292-64-6 |
| Chemical Name: | 2,6-dichloro-N-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-benzamide |
| Synonyms: | GDC-046,GDC 046 |
| 分子量: | 350.19884 |
| 分子式: | C16H13Cl2N3O2 |
| SMILES: | O=C(C1=C(Cl)C=CC=C1Cl)NC2=CC=NC(NC(C3CC3)=O)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GDC-046 是一种有效的，具有口服活性的选择性TYK2抑制剂，对TYK2，JAK1，JAK2和JAK3的Ki分别为 4.8、0.7、0.7 和 0.4 nM。 |
| IC50和靶点: | [{name:"Tyk2:4.8 nM (Ki)"},{name: "JAK1:0.7 nM (Ki)"},{name: "JAK2:0.7 nM (Ki)"},{name: "JAK3:0.4 nM (Ki)"}] |
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| Solvent & Solubility: |
Liang, J., van Abbema, A., Balazs, M., et al.Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitorsJ. Med. Chem.56(11),4521-4536(2013)
