Ac-Lys-AMC
Cat. No.：YN290595
| 产品名称: | Ac-Lys-AMC |
| CAS No.: | 1260635-77-5 |
| Chemical Name: | N1-hydroxy-N8-(4-methyl-2-oxo-2H-chromen-7-yl)-octanediamide |
| Synonyms: | |
| 分子量: | 346.4 |
| 分子式: | C18H22N2O5 |
| SMILES: | O=C(CCCCCCC(NO)=O)NC1=CC2=C(C(C)=CC(O2)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Coumarin-SAHA 是一种荧光探针 (fluorescent probe)，用于测定HDAC8抑制剂配合物的结合亲和性 (Kd) 和解离速率 (Koff)。 |
| IC50和靶点: | |
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Marks, P.A., and Breslow, R.Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drugNat. Biotechnol.25(1),84-90(2007)
Singh, R.K., Mandal, T., Balasubramanian, N., et al.Coumarin-suberoylanilide hydroxamic acid as a fluorescent probe for determining binding affinities and off-rates of histone deacetylase inhibitorsAnal. Biochem.408(2),309-315(2011)
