DPQ
Cat. No.：YN290599
| 产品名称: | DPQ |
| CAS No.: | 129075-73-6 |
| Chemical Name: | 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone |
| Synonyms: | |
| 分子量: | 302.4 |
| 分子式: | C18H26N2O2 |
| SMILES: | O=C1NCCC2=C(OCCCCN3CCCCC3)C=CC=C21 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | DPQ 是一种有效的PARP-1抑制剂。DPQ可降低 N- 甲基 -D- 天冬氨酸 (NMDA) 诱导的PARP激活，使 ATP 恢复到接近正常水平，且在 NMDA 严重暴露模型中显著减轻神经元损伤。DPQ 可用于神经保护研究。 |
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Fonfria, E., Marshall, I.C.B., Benham, C.D., et al.TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymeraseBr. J. Pharmacol.143,186-192(2004)
Giovannelli, L., Cozzi, A., Guarnieri, I., et al.Comet assay as a novel approach for studying DNA damage in focal cerebral ischemia: Differential effects of NMDA receptor antagonists and poly(ADP-ribose) polymerase inhibitorsJ. Cereb. Blood Flow Metab.22(6),697-704(2002)
