SR1664
Cat. No.：YN290607
CAS No. ：1338259-05-4
| 产品名称: | SR1664 |
| CAS No.: | 1338259-05-4 |
| Chemical Name: | 4'-[[2,3-dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]-[1,1'-biphenyl]-2-carboxylic acid |
| Synonyms: | SR 1664;SR1664 |
| 分子量: | 547.6 |
| 分子式: | C33H29N3O5 |
| SMILES: | C[C@H](NC(C1=CC=C(N(CC2=CC=C(C3=CC=CC=C3C(O)=O)C=C2)C(C)=C4C)C4=C1)=O)C5=CC=C([N+]([O-])=O)C=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SR1664是一种PPARγ拮抗剂。SR1664能结合PPARγ，并有效抑制Cdk5介导的PPARγ磷酸化 (IC50=80 nM;Ki= 28.67 nM)。 |
| IC50和靶点: | [{name:"PPAR-γ:80 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Norris, A.W., and Sigmund, C.D.A second chance for a PPARγ targeted therapy?: A commentary on "antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation"Circ. Res.110(1),8-11(2012)
Choi, J.H., Banks, A.S., Kamenecka, T.M., et al.Anti-diabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylationNature477(7365),477-481(2012)
