Fluzoparib
Cat. No.：YN290610
CAS No. ：1358715-18-0
| 产品名称: | Fluzoparib |
| CAS No.: | 1358715-18-0 |
| Chemical Name: | |
| Synonyms: | 氟唑帕利; SHR3162; Fuzuloparib |
| 分子量: | 472.4 |
| 分子式: | C22H16F4N6O2 |
| SMILES: | FC1C([H])=C([H])C(C([H])([H])C2C3=C([H])C([H])=C([H])C([H])=C3C(N([H])N=2)=O)=C([H])C=1C(N1C([H])([H])C2=NC(C(F)(F)F)=NN2C([H])([H])C1([H])[H])=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fluzoparib (SHR3162) 是一种有效的口服活性PARP1抑制剂(IC50=1.46±0.72 nM)，具有优越的抗肿瘤活性。Fluzoparib 选择性地抑制同源重组修复 (HR) 缺陷细胞的增殖，并使 HR 缺陷细胞对细胞毒性活性分子敏感。Fluzoparib 在体内具有良好的药代动力学特性，可用于癌症研究。 |
| IC50和靶点: | [{name:"PARP-1:1.46±0.72 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
