proTAME
Cat. No.：YN290611
| 产品名称: | proTAME |
| CAS No.: | 1362911-19-0 |
| Chemical Name: | (2S)-2-[[(4-methylphenyl)sulfonyl]amino]-9,13-dioxo-14-phenyl-7-[[[[(2-phenylacetyl)oxy]methoxy]carbonyl]amino]-10,12-dioxa-6,8-diazatetradec-6-enoic acid, methyl ester |
| Synonyms: | pro-Tosyl-L-Arginine Methyl Ester |
| 分子量: | 726.8 |
| 分子式: | C34H38N4O12S |
| SMILES: | CC1=CC=C(S(N[C@H](C(OC)=O)CCC/N=C(NC(OCOC(CC2=CC=CC=C2)=O)=O)/NC(OCOC(CC3=CC=CC=C3)=O)=O)(=O)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | proTAME 是 TAME 的一种细胞渗透性前体形式，是一种后期促进复合物/环体 (APC/C) 抑制剂。proTAME 导致细胞周期停滞在中期。 |
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Zeng, X., Sigoillot, F., Gaur, S., et al.Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damageCancer Cell18(4),382-395(2010)
Lub, S., Maes, A., De Veirman, K., et al.Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cellsOncotarget7(4),4062-4076(2016)
