Bisindolylmaleimide II
Cat. No.：YN310414
| 产品名称: | Bisindolylmaleimide II |
| CAS No.: | 137592-45-1 |
| Chemical Name: | 3-(1H-indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione |
| Synonyms: | Bis II |
| 分子量: | 438.5 |
| 分子式: | C27H26N4O2 |
| SMILES: | CN1CCCC1CCN2C3=CC=CC=C3C(C4=C(C5=CNC6=C5C=CC=C6)C(NC4=O)=O)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bisindolylmaleimide II 是所有蛋白激酶 C 亚型的通用抑制剂。 |
| IC50和靶点: | |
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Davis, P.D., Hill, C.H., Lawton, G., et al.Inhibitors of protein kinase C. 1.1 2,3-bisarylmaleimidesJ. Med. Chem.35(1),177-184(1992)
Toullec, D., Pianetti, P., Coste, H., et al.The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase CJ. Biol. Chem.266(24),15771-15781(1991)
Komander, D., Kular, G.S., Schüttelkopf, A.W., et al.Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1Structure12,215-226(2004)
Gassel, M., Breitenlechner, C.B., König, N., et al.The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase AJ. Biol. Chem.279(22),23679-23690(2004)
