BIX-01294 trihydrochloride
Cat. No.：YN310417
| 产品名称: | BIX-01294 trihydrochloride |
| CAS No.: | 1392399-03-9 |
| Chemical Name: | 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine Trihydrochloride; |
| Synonyms: | |
| 分子量: | 600.02 |
| 分子式: | C28H38N6O2.3HCl |
| SMILES: | CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC.Cl.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BIX-01294 trihydrochloride 是一种可逆且高度选择性的G9a和GLP组蛋白甲基转移酶抑制剂，IC50分别为 1.9 μM 和 0.7 μM。BIX-01294 trihydrochloride 通过与底物赖氨酸残基 N 端的氨基酸竞争结合来抑制 G9a/GLP。BIX-01294 trihydrochloride 是一种 (1H-1,4-diazepin-1-yl)-quinazolin-4-yl 胺衍生物，可诱导坏死性凋亡 (necroptosis) 和自噬。BIX-01294 |
| IC50和靶点: | |
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Kubicek, S. et al.: Mol. Cell., 25, 473 (2007)
Huangfu, D et al.: Nat. Biotechnol., 26, 795 (2008)
Chang, Y. et al.: Bat. Struct. Mol. Biol., 16, 312 (2009)
