hSMG-1 inhibitor 11j
Cat. No.：YN290620
CAS No. ：1402452-15-6
| 产品名称: | hSMG-1 inhibitor 11j |
| CAS No.: | 1402452-15-6 |
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| 分子量: | 566.077 |
| 分子式: | C27H28ClN7O3S |
| SMILES: | C(S(N(CC)CC)(=O)=O)1=CC(NC2=NC=CC(C3C=CN=C(C4=CC=C(NC(NC)=O)C=C4)C=3)=N2)=CC=C1Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | hSMG-1 inhibitor 11j，一种嘧啶衍生物，是有效的和选择性的hSMG-1抑制剂，IC50值为 0.11 nM。hSMG-1 inhibitor 11j 对 hSMG-1 的选择性是mTOR(IC50=50 nM)，PI3Kα/γ(IC50=92/60 nM) 和CDK1/CDK2(IC50=32/7.1 μM) 的 455 倍以上。hSMG-1 inhibitor 11j 可用于癌症研究。 |
| IC50和靶点: | [{name:"hSMG-1:0.11 nM (IC50)"},{name: "mTOR:50 nM (IC50)"},{name: "PI3Kγ:60 nM (IC50)"},{name: "PI3Kα:92 nM (IC50)"},{name: "GSKα:260 (IC50)"},{name: "GSKβ:330 (IC50)"},{name: "CDK2:7.1 μM (IC50)"},{name: "CDK1:32 μM (IC50)"}] |
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Gopalsamy, A., et al.: Bioorg. Med. Chem. Lett., 22, 6636 (2012)
