Chetomin
Cat. No.：YN290621
| 产品名称: | Chetomin |
| CAS No.: | 1403-36-7 |
| Chemical Name: | 2,3S,5aR,6,10bS,11-hexahydro-3-(hydroxymethyl)-10b-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-3,11aS-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione |
| Synonyms: | 3,11a-Epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione,2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-,(3S,5a |
| 分子量: | 710.9 |
| 分子式: | C31H30N6O6S4 |
| SMILES: | O=C(C1(CC2=CN([C@@]34C5=CC=CC=C5N[C@]3([H])N(C([C@@]6(CO)N(C)C7=O)=O)[C@]7(SS6)C4)C8=C2C=CC=C8)N9C)N(C)[C@@](CO)(SS1)C9=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Chetomin 作为 Chaetomium globosum 的活性成分，是一种热休克蛋白90/缺氧诱导因子1α (Hsp90/HIF1α) 途径的抑制剂。Chetomin 是一种有效的、无毒的非小细胞肺癌干细胞 (NSCLC CSC) 靶向分子。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Mazumder, P.M., and Sasmal, D.Mycotoxins - limits and regulationsAnc. Sci. Life20(3),1-19(2001)
Kung, A.L., Zabludoff, S.D., France, D.S., et al.Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathwayCancer Cell6,33-43(2004)
Kessler, J., Hahnel, A., Wichmann, H., et al.HIF-1α inhibition by siRNA or chetomin in human malignant glioma cells: Effects on hypoxic radioresistance and monitoring via CA9 expressionBMC Cancer10(605),(2010)
