BRD6688
Cat. No.：YN310418
| 产品名称: | BRD6688 |
| CAS No.: | 1404562-17-9 |
| Chemical Name: | N-[2-amino-5-(4-pyridinyl)phenyl]-1-pyrrolidinecarboxamide |
| Synonyms: | BRD6688 |
| 分子量: | 282.3 |
| 分子式: | C16H18N4O |
| SMILES: | O=C(N1CCCC1)NC2=CC(C3=CC=NC=C3)=CC=C2N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BRD6688 是一种选择性的HDAC2抑制剂。BRD6688 增加原代小鼠神经元细胞中的 H4K12 和 H3K9 组蛋白乙酰化。在 CK-p25 小鼠模型中，BRD6688 透过血脑屏障，缓解与 p25 诱导的神经退行性病变相关的记忆缺陷。 |
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| Solvent & Solubility: |
Wagner, F.F., Zhang, Y.-L., Fass, D.M., et al.Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancersChem. Sci.6(1),804-815(2015)
