Darglitazone
Cat. No.：YN290623
| 产品名称: | Darglitazone |
| CAS No.: | 141200-24-0 |
| Chemical Name: | 5-[[4-[3-(5-methyl-2-phenyl-4-oxazolyl)-1-oxopropyl]phenyl]methyl]-2,4-thiazolidinedione |
| Synonyms: | CP-86325 |
| 分子量: | 420.5 |
| 分子式: | C23H20N2O4S |
| SMILES: | O=C(CCC1=C(C)OC(C2=CC=CC=C2)=N1)C3=CC=C(CC4SC(NC4=O)=O)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Darglitazone (CP-86325)，一种噻唑烷二酮，是一种有效的，选择性的和具有口服活性的PPAR-γ激动剂。Darglitazone 有效控制血糖和脂质代谢，可用于 II 型糖尿病研究。 |
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Willson, T.M., Cobb, J.E., Cowan, D.J., et al.The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinedionesJ. Med. Chem.39(3),665-668(1996)
Cantello, B.C.C., Cawthorne, M.A., Cottam, G.P., et al.[[ω-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agentsJ. Med. Chem.37,3977-3985(1994)
Zhang, B., Szalkowski, D., Diaz, E., et al.Potentiation of insulin stimulation of phosphatidylinositol 3-kinase by thiazolidinedione-derived antidiabetic agents in Chinese hamster ovary cells expressing human insulin receptors and L6 myotubesJ. Biol. Chem.269(41),25735-25741(1994)
Chaiken, R.L., Eckert-Norton, M., Pasmantier, R., et al.Metabolic effects of darglitazone, an insulin sensitizer, in NIDDM subjectsDiabetologia38,1307-1312(1995)
Camirand, A., Marie, V., Rabelo, R., et al.Thiazolidinediones stimulate uncoupling protein-2 expression in cell lines representing white and brown adipose tissues and skeletal muscleEndocrinology139(1),428-431(1998)
Kumari, R., Willing, L.B., Patel, S.D., et al.The PPAR-γ agonist, darglitazone, restores acute inflammatory responses to cerebral hypoxia-ischemia in the diabetic ob/ob mouseJ. Cereb. Blood Flow Metab.30(2),352-360(2010)
