MI-192
Cat. No.：YN290625
| 产品名称: | MI-192 |
| CAS No.: | 1415340-63-4 |
| Chemical Name: | N-(2-aminophenyl)-4-[(3,4-dihydro-4-methylene-1-oxo-2(1H)-isoquinolinyl)methyl]-benzamide |
| Synonyms: | MI-192; MI 192; MI192. |
| 分子量: | 383.4 |
| 分子式: | C24H21N3O2 |
| SMILES: | O=C1N(CC2=CC=C(C(NC3=CC=CC=C3N)=O)C=C2)CC(C4=CC=CC=C41)=C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MI-192 是一种选择性HDAC2和HDAC3抑制剂，IC50分别为 30 nM 和 16 nM。MI-192 对 HDAC2/3 的选择性比其他HDAC异构体更高。MI-192 诱导髓系白血病细胞凋亡 (apoptosis)。抗癌和神经保护活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Boissinot, M., Inman, M., Hempshall, A., et al.Induction of differentiation and apoptosis in leukaemic cell lines by the novel benzamide family histone deacetylase 2 and 3 inhibitor MI-192Leuk. Res.36,1304-1310(2012)
