CRT0066854
Cat. No.：YN290631
CAS No. ：1438881-19-6
| 产品名称: | CRT0066854 |
| CAS No.: | 1438881-19-6 |
| Chemical Name: | (2S)-3-phenyl-N1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-1,2-propanediamine |
| Synonyms: | CRT0066854; CRT-0066854; CRT 0066854; CRT-0066854 HCl |
| 分子量: | 415.555 |
| 分子式: | C24H25N5S |
| SMILES: | N[C@@H](CC1=CC=CC=C1)CNC2=C3C(SC4=C3CCCC4)=NC(C5=CC=NC=C5)=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CRT0066854 是一种强效选择性非典型PKC同工酶抑制剂。CRT0066854 抑制PKCι，PKCζ和ROCK-II的IC50的值分别为 132nM，639 nM 和 620 nM。 |
| IC50和靶点: | [{name:"PKCζ:639 nM (IC50)"},{name: "ROCK2:620 nM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Kjær, S., Linch, M., Purkiss, A., et al.Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymesBiochem. J.451(2),329-342(2013)
