Bisindolylmaleimide XI hydrochloride
Cat. No.：YN310424
| 产品名称: | Bisindolylmaleimide XI hydrochloride |
| CAS No.: | 145333-02-4 |
| Chemical Name: | 3-[8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione, monohydrochloride |
| Synonyms: | Ro 32-0432; Ro 31-8830 hydrochloride |
| 分子量: | 489 |
| 分子式: | C28H28N4O2 • HCl |
| SMILES: | O=C(NC1=O)C(C2=CNC3=C2C=CC=C3)=C1C4=C5N(CCC(CN(C)C)C5)C6=CC=CC=C64.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bisindolylmaleimide XI hydrochloride (Ro 32-0432) 是一种有效、选择性和具有口服活性的PKC抑制剂，对PKCα、PKCβI、PKCβII、PKCγ的IC50分别为 9 nM、28 nM、31 nM、37 nM 和 108 nM。 |
| IC50和靶点: | [{name:"PKC-α:9 nM (IC50)"},{name: "PKC-βI:28 nM (IC50)"},{name: "PKC-βII:31 nM (IC50)"},{name: "PKC-γ:37 nM (IC50)"},{name: "PKC-ε:108 nM (IC50)"}] |
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Wilkinson, S.E., Parker, P.J., and Nixon, J.S.Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase CBiochem. J.294(Pt 2),335-337(1993)
Liu, Q., Chen, X., MacDonnell, S.M., et al.PKCα, but not PKCβ or PKCγ, regulates contractility and heart failure susceptibility: Implications for ruboxistaurin as a novel therapeutic approachCirc. Res.105(2),194-200(2009)
Birchall, A.M., Bishop, J., Bradshaw, D., et al.Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activationJ. Pharmacol. Exp. Ther.268(2),922-929(1994)
