CGP-53353
Cat. No.：YN310426
CAS No. ：145915-60-2
| 产品名称: | CGP-53353 |
| CAS No.: | 145915-60-2 |
| Chemical Name: | 5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione; DAPH 7; 5,6-Bis(4-fluoroanilino)isoindole-1,3-dione |
| Synonyms: | DAPH-7 |
| 分子量: | 365.33 |
| 分子式: | C20H13F2N3O2 |
| SMILES: | FC1C=CC(NC2C=C3C(NC(=O)C3=CC=2NC2C=CC(F)=CC=2)=O)=CC=1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CGP-53353 (DAPH-7) 是一种有效的PKC抑制剂，对 PKCβII 和 PKCβI 的IC50分别为 0.41 μM 和 3.8 μM。CGP-53353 能在 AoSMC 和 A10 细胞中抑制葡萄糖诱导的细胞增殖和 DNA 合成 (DNA synthesis)。CGP-53353 可用于糖尿病患者动脉粥样硬化的研究。 |
| IC50和靶点: | [{name:"PKCβII:0.41 mM (IC50)"},{name: "PKCβI:3.8 mM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Dinney, C., et al.: Clin. Cancer Res., 3, 161 (1997)
