PF-06685249
Cat. No.：YN310427
CAS No. ：1467059-70-6
| 产品名称: | PF-06685249 |
| CAS No.: | 1467059-70-6 |
| Chemical Name: | 6-chloro-5-[6-(dimethylamino)-2-methoxy-3-pyridinyl]-1H-indole-3-carboxylic acid |
| Synonyms: | PF-249 |
| 分子量: | 345.78006 |
| 分子式: | C17H16ClN3O3 |
| SMILES: | O=C(C1=CNC2=C1C=C(C3=C(OC)N=C(N(C)C)C=C3)C(Cl)=C2)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-06685249 (PF-249) 是一种有效的、具有口服活性的变构AMPK激活剂，对重组AMPK α1β1γ1的EC50为 12 nM。PF-06685249 可用于糖尿病肾病研究。 |
| IC50和靶点: | [{name:"AMPK α1β1γ1:12 nM (EC50)"}] |
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| Solvent & Solubility: |
Salatto, C.T., Miller, R.A., Cameron, K.O., et al.Selective activation of AMPK β1-containing isoforms improves kidney function in a rat model of diabetic nephropathyJ. Pharmacol. Exp. Ther.361(2),303-311(2017)
Ryder, T.F., Calabrese, M.F., Walker, G.S., et al.Acyl glucuronide metabolites of 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid (PF-06409577) and related indole-3-carboxylic acid derivatives are direct activators of adenosine monophosphate-activated protein kinase (AMPK)J. Med. Chem.61(16),7273-7288(2018)
