SCR7
Cat. No.：YN290640
| 产品名称: | SCR7 |
| CAS No.: | 1533426-72-0 |
| Chemical Name: | 2,3-dihydro-5,6-bis[(E)-(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone |
| Synonyms: | SCR-7 |
| 分子量: | 334.39612 |
| 分子式: | C18H14N4OS |
| SMILES: | O=C(C1=NC(C2=CC=CC=C2)=C(C3=CC=CC=C3)NC1=N4)NC4=S |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SCR7 是一种不稳定的形式，可以自动循环成稳定形式的 SCR7 pyrazine。SCR7 pyrazine 是一种 DNA 连接酶 IV (DNA ligase IV) 抑制剂，它以连接酶 IV 依赖的方式阻断非同源末端连接 (NHEJ)。SCR7 也是一种CRISPR/Cas9的增强子，可提高 Cas9 介导的同源性定向修复 (HDR) 的效率。SCR7 pyrazine 诱导细胞凋亡 (apoptosis) 并具有抗癌活性。 |
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Srivastava, M., Nambiar, M., Sharma, S., et al.An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progressionCell151(7),1474-1487(2012)
Chu, V.T., Weber, T., Wefers, B., et al.Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cellsNat. Biotechnol.33(5),543-550(2015)
John, F., George, J., Srivastava, M., et al.Pluronic copolymer encapsulated SCR7 as a potential anticancer agentFaraday Discussions177,1-7(2014)
Maruyama, T., Dougan, S.K., Truttmann, M.C., et al.Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joiningNat. Biotechnol.33(5),538-542(2015)
