CHM-1
Cat. No.：YN290641
| 产品名称: | CHM-1 |
| CAS No.: | 154554-41-3 |
| Chemical Name: | 6-(2-fluorophenyl)-1,3-dioxolo[4,5-g]quinolin-8(5H)-one |
| Synonyms: | NSC656158 |
| 分子量: | 283.2539432 |
| 分子式: | C16H10FNO3 |
| SMILES: | O=C(C=C(C1=C(F)C=CC=C1)N2)C3=C2C=C(OCO4)C4=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CHM-1 是一种微管失稳剂，可抑制微管蛋白聚合。CHM-1 是一种有效且选择性的抗人肝癌有丝分裂的抗肿瘤活性。CHM-1 通过激活 Cdc2 激酶活性诱导人肝癌细胞 G2-M 期阻滞，从而诱导细胞生长抑制和凋亡。 |
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Xia, Y., Yang, Z.-Y., Xia, P., et al.Antitumor agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agentsJ. Med. Chem.44(23),3932-3936(2001)
Wang, S.-W., Pan, S.-L., Huang, Y.-C., et al.CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivoMol. Cancer Ther.7(2),350-360(2008)
