GSK199
Cat. No.：YN310428
| 产品名称: | GSK199 |
| CAS No.: | 1549811-53-1 |
| Chemical Name: | [(3R)-3-amino-1-piperidinyl][2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-methanone, monohydrochloride |
| Synonyms: | |
| 分子量: | 469 |
| 分子式: | C24H28N6O2 • HCl |
| SMILES: | N[C@H]1CN(C(C2=CC(N=C(C3=CC(C=CC=N4)=C4N3CC)N5C)=C5C(OC)=C2)=O)CCC1.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK199 是一种可逆的选择性PAD4抑制剂，在缺少钙离子的情况下，其IC50为 200 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Jones, J.E., Causey, C.P., Knuckley, B., et al.Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potentialCurr. Opin. Drug Discov. Devel.12(5),616-627(2009)
Lewis, H.D., Liddle, J., Coote, J.E., et al.Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formationNat. Chem. Biol.11(3),189-191(2015)
