Safingol
Cat. No.：YN310429
| 产品名称: | Safingol |
| CAS No.: | 15639-50-6 |
| Chemical Name: | (2S,3S)-2-amino1,3-octadecanediol |
| Synonyms: | L-threo-dihydrosphingosine |
| 分子量: | 301.5 |
| 分子式: | C18H39NO2 |
| SMILES: | OC[C@H](N)[C@@H](O)CCCCCCCCCCCCCCC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Safingol 是溶血磷脂PKC(蛋白激酶 C) 的抑制剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Wilson, E., Olcott, M.C., Bell, R.M., et al.Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burstJ. Biol. Chem.261(27),12616-12623(1986)
Baek, D.J., Macritchie, N., Anthony, N.G., et al.Structure-activity relationships and molecular modeling of sphingosine kinase inhibitorsJ. Med. Chem.56(22),9310-9327(2013)
Matula, K., Collie-Dugid, E., Murray, G., et al.Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancerBMC Cancer15:762,(2015)
