Netoglitazone
Cat. No.：YN290649
CAS No. ：161600-01-7
| 产品名称: | Netoglitazone |
| CAS No.: | 161600-01-7 |
| Chemical Name: | 5-[[6-[(2-fluorophenyl)methoxy]-2-naphthalenyl]methyl]-2,4-thiazolidinedione |
| Synonyms: | MCC-555; Isaglitazone |
| 分子量: | 381.4 |
| 分子式: | C21H16FNO3S |
| SMILES: | FC1=CC=CC=C1COC2=CC(C=CC(CC3SC(NC3=O)=O)=C4)=C4C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Netoglitazone 是PPARα和PPARγ的双重激动剂，具有降血糖活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Willson, T.M., Cobb, J.E., Cowan, D.J., et al.The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinedionesJ. Med. Chem.39(3),665-668(1996)
Cantello, B.C.C., Cawthorne, M.A., Cottam, G.P., et al.[[ω-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agentsJ. Med. Chem.37,3977-3985(1994)
Lehmann, J.M., Moore, L.B., Smith-Oliver, T.A., et al.An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ)J. Biol. Chem.270(22),12953-12956(1995)
Reginato, M.J., Bailey, S.T., Krakow, S.L., et al.A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor g -activating propertiesJ. Biol. Chem.273,32679-32684(1998)
