AG-636
Cat. No.：YN290650
CAS No. ：1623416-31-8
| 产品名称: | AG-636 |
| CAS No.: | 1623416-31-8 |
| Chemical Name: | 1-methyl-5-(2′-methyl[1,1′-biphenyl]-4-yl)-1H-benzotriazole-7-carboxylic acid |
| Synonyms: | |
| 分子量: | 343.3787 |
| 分子式: | C21H17N3O2 |
| SMILES: | O=C(C1=CC(C2=CC=C(C3=C(C)C=CC=C3)C=C2)=CC4=C1N(C)N=N4)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AG-636 是一种有效，可逆，选择性和具有口服活性的二氢乳清酸脱氢酶(DHODH)抑制剂，IC50为 17 nM。AG-636 具有很强的抗癌作用。 |
| IC50和靶点: | |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
McDonald, G., Chubukov, V., Coco, J., et al.Selective vulnerability to pyrimidine starvation in hematologic malignancies revealed by AG-636, a novel clinical-stage inhibitor of dihydroorotate dehydrogenaseMol. Cancer Ther.19(12),2502-2515(2020)
