EPZ020411
Cat. No.：YN310436
CAS No. ：1700663-41-7
| 产品名称: | EPZ020411 |
| CAS No.: | 1700663-41-7 |
| Chemical Name: | N1,N2-dimethyl-N1-[[3-[4-[[trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl]oxy]phenyl]-1H-pyrazol-4-yl]methyl]-1,2-ethanediamine |
| Synonyms: | EPZ020411;EPZ-020411;N,N'-Dimethyl-N-({3-[4-({trans-3-[2-(Tetrahydro-2h-Pyran-4-Yl)ethoxy]cyclobutyl}oxy)phenyl]-1h-Pyrazol-4-Yl}methyl)ethane-1,2-Diamine;N,N'-dimethyl-N'-[[5-[4-[3-[2-(oxan-4-yl)ethoxy]cyclobutyl]oxyphenyl]-1H-pyrazol-4-yl]methyl]ethane- |
| 分子量: | 442.6 |
| 分子式: | C25H38N4O3 |
| SMILES: | CN(CCNC)CC1=CNN=C1C(C=C2)=CC=C2O[C@H](C3)C[C@@H]3OCCC4CCOCC4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | EPZ020411 是一种选择性的PRMT6抑制剂，其IC50值为10 nM，对PRMT6的选择性是PRMT1和PRMT8的10倍。EPZ020411 可用于癌症的研究。 |
| IC50和靶点: | [{name:"PRMT6:0.01 μM (IC50)"},{name: "PRMT1:0.119 μM (IC50)"},{name: "PRMT8:0.223 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Mitchell, L.H., Drew, A.E., Ribich, S.A., et al.Aryl pyrazoles as potent inhibitors of arginine methyltransferases: Identification of the first PRMT6 tool compoundACS Med. Chem. Lett.6(6),655-659(2015)
