Hsp90-IN-17 hydrochloride
Cat. No.：YN290659
| 产品名称: | Hsp90-IN-17 hydrochloride |
| CAS No.: | 171009-07-7 |
| Chemical Name: | 4-[4-(2,3-dihydo-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol |
| Synonyms: | CCT018159 |
| 分子量: | 352.4 |
| 分子式: | C20H20N2O4 |
| SMILES: | CCc1cc(c(O)cc1O)c1n[nH]c(C)c1c1ccc2OCCOc2c1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CCT018159 是一种 3,4-二芳基吡唑间苯二酚，一种 ATP 竞争性HSP90ATPase 活性抑制剂，对人 Hsp90β 和酵母Hsp90的IC50分别为 3.2 和 6.6 µM。CCT018159 引起与 G1 期阻滞相关的细胞细胞抑制并诱导细胞凋亡。CCT018159 抑制与侵袭和血管生成有关的关键内皮细胞和肿瘤细胞功能。 |
| IC50和靶点: | [{name:"human Hsp90β:3.2 μM (IC50)"},{name: "yeast Hsp90:6.6 μM (IC50)"}] |
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| Solvent & Solubility: |
Sharp, S.Y., Boxall, K., Rowlands, M., et al.In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitorsCancer Res.67(5),2206-2216(2007)
