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4-Aminonaphthalimide

Cat. No.:YN290660

  • CAS No. :1742-95-6

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    • 生物活性
    • 参考文献
    • 产品名称: 4-Aminonaphthalimide
      CAS No.: 1742-95-6
      Chemical Name: 6-amino-1H-benz[de]isoquinoline-1,3(2H)-dione
      Synonyms:
      分子量:212.2
      分子式:C12H8N2O2
      SMILES:NC1=C2C(C3=CC=C2)=C(C=C1)C(NC3=O)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: 4-Aminonaphthalimide 是一种有效的PARP抑制剂,可使癌细胞对 γ 辐射诱导的细胞毒性敏感。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Davar, D., Beumer, J.H., Hamieh, L., et al.Role of PARP inhibitors in cancer biology and therapyCurr. Med. Chem.19(23),3907-3921(2012)

      Mathews, M.T., and Berk, B.C.PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2Arterioscler. Thromb. Vasc. Biol.28,711-717(2008)

      Banasik, M., Komura, H., Shimoyama, M., et al.Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferaseJ. Biol. Chem.267(3),1569-1575(1992)

      Schlicker, A., Peschke, P., Burkle, A., et al.4-Amino-1,8-naphthalimide: A novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizerInt. J. Radiat. Biol.75(1),91-100(1999)

      Issaeva, N., Thomas, H.D., Djureinovic, T., et al.6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistanceCancer Res.70(15),6268-6276(2010)

      Horton, J.K., Stefanick, D.F., Gassman, N.R., et al.Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responsesDNA Repair (Amst)12(9),774-785(2013)

      Luo, Q., Li, Y., Lai, Y., et al.The role of NF-κB in PARP-inhibitor-mediated sensitization and detoxification of arsenic trioxide in hepatocellular carcinoma cellsJ. Toxicol. Sci.40(3),349-363(2015)

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