RN-1 dihydrochloride
Cat. No.：YN310438
CAS No. ：1781835-13-9
| 产品名称: | RN-1 dihydrochloride |
| CAS No.: | 1781835-13-9 |
| Chemical Name: | rel-1-(4-methyl-1-piperazinyl)-2-[[(1R,2S)-2-[4-(phenylmethoxy)phenyl]cyclopropyl]amino]-ethanone, dihydrochloride |
| Synonyms: | RN1, RN 1 |
| 分子量: | 452.4 |
| 分子式: | C23H29N3O2 • 2HCl |
| SMILES: | CN1CCN(C(CN[C@@H]2[C@@H](C3=CC=C(OCC4=CC=CC=C4)C=C3)C2)=O)CC1.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RN-1 dihydrochloride 是一种有效的、可透过血脑屏障、不可逆的、选择性的赖氨酸特异性脱甲基酶 1 (LSD1) 抑制剂，IC50为 70 nM。RN-1 dihydrochloride 对 LSD1 的选择性高于MAO-A和MAO-B，IC50值分别为 0.51 μM 和 2.785 μM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Shi, Y., Lan, F., Matson, C., et al.Histone demethylation mediated by the nuclear amine oxidase homolog LSD1Cell119(7),941-953(2004)
Neelamegam, R., Ricq, E.L., Malvaez, M., et al.Brain-penetrant LSD1 inhibitors can block memory consolidationACS Chem. Neurosci.3(2),120-128(2012)
Konovalov, S., and Garcia-Bassets, I.Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell linesJ. Ovarian Res.6(1),75(2013)
Cui, S., Lim, K.C., Shi, L., et al.The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell miceBlood126(3),286-296(2015)
