LP99
Cat. No.：YN310441
CAS No. ：1808951-93-0
| 产品名称: | LP99 |
| CAS No.: | 1808951-93-0 |
| Chemical Name: | N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-1-propanesulfonamide |
| Synonyms: | LP99;LP-99;LP 99 |
| 分子量: | 516.1 |
| 分子式: | C26H30ClN3O4S |
| SMILES: | CC(C1=CC=C(N2C(CC[C@H](NS(CC(C)C)(=O)=O)[C@H]2C3=CC=C(Cl)C=C3)=O)C=C1N4C)=CC4=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LP99，表观遗传探针，是一种有效的选择性的BRD7和BRD9溴脱氧核糖的抑制剂，对BRD9的Kd为 99 nM。LP99 破坏BRD7和BRD9与细胞染色质的结合。 |
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Clark, P.G., Vieira, L.C., Tallant, C., et al.LP99: Discovery and synthesis of the first selective BRD7/9 bromodomain inhibitorAngew. Chem. Int. Ed. Engl.54(21),6217-6221(2015)
Karim, R.M., and Schönbrunn, E.An advanced tool to interrogate BRD9J. Med. Chem.59(10),4459-4461(2016)
