AZ9482
Cat. No.：YN290664
| 产品名称: | AZ9482 |
| CAS No.: | 1825345-33-2 |
| Chemical Name: | 2-[4-[3-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]benzoyl]-1-piperazinyl]-3-pyridinecarbonitrile |
| Synonyms: | AZ 9482,AZ-9482 |
| 分子量: | 450.49212 |
| 分子式: | C26H22N6O2 |
| SMILES: | O=C1C2=CC=CC=C2C(CC3=CC(C(N4CCN(C5=NC=CC=C5C#N)CC4)=O)=CC=C3)=NN1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZ9482 是PARP1/2/6的三重抑制剂，其对 PARP1/2/6 的IC50值分别为 1 nM、1 nM 和640 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Johannes, J.W., Almeida, L., Daly, K., et al.Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clusteringBioorg. Med. Chem. Lett.25(24),5743-5747(2015)
