ZLD1039
Cat. No.：YN310446
| 产品名称: | ZLD1039 |
| CAS No.: | 1826865-46-6 |
| Chemical Name: | 3-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-N-[(2,3,5,6,7,8-hexahydro-1-methyl-3-oxo-4-isoquinolinyl)methyl]-2-methyl-5-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-benzamide |
| Synonyms: | ZLD1039;3-[Ethyl(tetrahydro-2H-pyran-4-yl)amino]-N-[(2,3,5,6,7,8-hexahydro-1-methyl-3-oxo-4-isoquinolinyl)methyl]-2-methyl-5-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-benzamide;ZLD 1039;J3.544.027E;3-[Ethyl(tetrahydro-2H-pyran-4-yl)amino]-N-[(2,3,5,6,7,8-h |
| 分子量: | 612.8 |
| 分子式: | C36H48N6O3 |
| SMILES: | CN1CCN(C2=NC=C(C3=CC(N(C4CCOCC4)CC)=C(C)C(C(NCC5=C(CCCC6)C6=C(C)NC5=O)=O)=C3)C=C2)CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ZLD1039 是一种口服有效的、高选择性EZH2抑制剂。ZLD1039 高效抑制EZH2野生型及 Y641F 和 A677G 突变型，IC50分别为 5.6、15 和 4.0 nM。ZLD1039 抑制乳腺肿瘤的生长和转移。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Song, X., Gao, T., Wang, N., et al.Selective inhibition of EZH2 by ZLD1039 blocks H3K27methylation and leads to potent anti-tumor activity in breast cancerSci. Rep.6:20864,(2016)
